The focus of our research at the National Institutes of Health (NIH) is to understand the basic mechanisms that regulate DNA replications and gene expression at the beginning of animal development. To this end, we are learning how mammalian cells determine when and where to initiate DNA replications, and how this process is regulated. We are also learning how fertilization of mammalian eggs activates the program for selective gene expression during the production and subsequen differentiation of embryonic stem cells.

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Dr. DePamphilis served as an editor or co-editor for the following books.

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Concepts in Eukaryotic DNA ReplicationDNA Replication and Human DiseaseDNA Replication in Eukaryotic CellsGene Expression at the Beginning of Animal DevelopmentMethods in Enzymology

Page Last Updated: 07/09/08