Dr. Melvin DePamphilisOur goal is to identify mechanisms that regulate genome duplication during mammalian development and target them in the treatment of human disease. How do cells decide when and where to initiate DNA replication? How do they restrict genome duplication to once per cell division? How do some cells undergo multiple rounds of genome duplication without dividing and remain viable? To these ends, we are (1) identifying genes that are essential to prevent excess DNA replication dependent apoptosis selectively in cancer cells, (2) inactivating geminin in cancer stem cells as a means to selectively kill cancers, and (3) exploring the use of novel, highly efficient, inducers of autophagy in the treatment of neurodegenerative diseases (e.g. Huntington’s) and cancer.

Two Mice

Books edited or authored by MLD (click on cover to view table of contents).

book cover for DNA Replicationbook cover for Genome DuplicationConcepts in Eukaryotic DNA ReplicationDNA Replication and Human DiseaseDNA Replication in Eukaryotic CellsGene Expression at the Beginning of Animal DevelopmentMethods in Enzymology

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Last Updated: 2/1/16